1-Bromopropane
1-Bromopropane is the straight-chain propyl bromide used as a Grignard raw material, as an alkylating agent for aromatic compounds and as a named intermediate for prothiamine and probenecid. It is supplied as a colourless liquid at 99.5% minimum purity with moisture held to 300 ppm maximum by Karl Fischer.
What You Get With This Grade
- Moisture specified at 300 ppm maximum by Karl Fischer, which is the number Grignard chemistry lives on
- Purity 99.5% minimum by GC
- Colour value 20 APHA maximum so colour bodies entering the route are bounded
- 180 kg drums or tank truck, packed to your handling requirement
Technical features
- Colourless liquid
- Used as solvent and laboratory reagent as well as synthesis raw material
- Purity determined by gas chromatography
- Moisture determined by Karl Fischer titration
Where 1-Bromopropane Is Used
Grignard reagent preparation
Used as a raw material for Grignard reagents where dry conditions decide whether the reaction initiates.
Aromatic alkylation
Serves as an alkylating agent for aromatic compounds.
Pharmaceutical intermediates
An intermediate for drugs such as prothiamine and probenecid.
Manufacture of medicines pesticides dyes and fragrances
Used across all four, and as a solvent and laboratory reagent.
Buyers This Grade Is Built For
- Process chemists running Grignard steps who specify water in ppm not percent
- API manufacturers making prothiamine or probenecid
- Dye and fragrance producers needing a propyl bromide handle
- Laboratories requiring reagent quality material in drum quantities
What It Stops Going Wrong
- A few hundred ppm of extra water quenches a Grignard initiation and the batch is lost
- Purity quoted without a GC method is not something QA can accept
- Colour bodies carried into an API route show up in the impurity profile
- Halogenated material shipped without a DG plan gets held at the port
Quality Index for 1-Bromopropane
| CAS number | 106-94-5 |
|---|---|
| Molecular formula | C3H7Br |
| Molecular weight | 122.99 |
| Appearance | Colourless liquid |
| Purity by GC | 99.5% minimum |
| Moisture by Karl Fischer | 300 ppm maximum |
| Colour value | 20 APHA maximum |
How It Ships and How to Store It
Packing
- 180 kg per drum
- Tank truck for bulk
- Can be packaged according to user requirements
Storage and transport
- Store as dangerous goods under the applicable regulations
- Keep containers sealed, since the moisture specification is only meaningful if it survives storage
How the Lot Is Released
Purity by GC, moisture by Karl Fischer and APHA colour are checked against the quality index before release, with SDS and COA available.
What We Can Change
Drum or tank truck, packed according to user requirements. Send your intake standard with the enquiry.
Against the Alternatives
1-Bromopropane is the n-propyl isomer; 2-bromopropane is the isopropyl isomer at the same 122.99 molecular weight. Both serve Grignard chemistry, but 1-bromopropane is the one named as an aromatic alkylating agent and as the prothiamine and probenecid intermediate, while 2-bromopropane is named for napropamide. 1-Bromopropane carries the tighter moisture specification at 300 ppm.
Handling 1-Bromopropane on Your Site
Written for the person who receives the drum, not for a brochure.
- Verify the Karl Fischer result on the COA before charging a Grignard reactor
- Keep drums sealed and dry in store so the 300 ppm figure still applies at point of use
- Handle and ship as dangerous goods
- Check the APHA colour figure where the downstream product has a colour specification
1-Bromopropane FAQ
What moisture level does it carry?
300 ppm maximum by Karl Fischer, with purity at 99.5% minimum by GC.
Is it suitable for Grignard reagent preparation?
Yes, it is used as a raw material for Grignard reagents and as an alkylating agent for aromatic compounds.
Which pharmaceutical intermediates does it feed?
It is an intermediate for drugs such as prothiamine and probenecid.
What is the colour specification?
20 APHA maximum.
How is it packed?
180 kg per drum, or by tank truck, and it can be packaged according to user requirements.
How does it differ from 2-bromopropane?
Same molecular weight and same 99.5% purity, but 1-bromopropane is the straight-chain isomer with a tighter 300 ppm moisture limit, while 2-bromopropane is the isopropyl isomer specified at 0.05% water.
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