WesynTech (Shanghai) Pharmaceutical Technology Co., Ltd

Preclinical & Process Development

The jump from milligrams to the first kilo is where routes break. Pilot equipment and the chemists who wrote the route sit in the same building here.

The pressure

What actually goes wrong

Preclinical programmes need more material than discovery produced, made by a route that will survive scrutiny. The discovery route usually will not: it has a cryogenic step nobody costed, a chromatography that cannot scale, or a palladium residue nobody measured.

The answer

Pilot-scale reality check

Two 20 L and six 50 L reactors covering −70 °C to 200 °C mean the route can be tested at scale rather than argued about on paper.

Residue and impurity work

Metal residues from homogeneous catalysts are treated as a development problem with a documented approach, not left to the final purification.

Continuity into supply

The same route carries into repeat production, in-house up to the hundred-kilogram range and through partner plants beyond it.

Pilot-plant reactor used for preclinical scale-up batches at WesynTech
Pilot-plant reactor used for preclinical scale-up batches at WesynTech.

What this looks like in practice

  • Route optimisation before scale, not after a failed batch
  • Cryogenic and high-temperature chemistry under one roof
  • Documented handover into repeat production

Tell us what is holding the programme up

One structure, one quantity, one date. That is enough for the team to say whether it is a catalogue answer or a custom synthesis project.